Bacterial Cellulose/Chitosan Hydrogels Synthesized In situ for Biomedical Application

Objective: Bacterial cellulose (BC) is a biopolymer whose application has been limited due to the difficulty introduce modifiable functional groups onto its network. The present study introduces new from chitosan (Chs) by in-situ method and further modified crosslinking with genipin (Gp), non-toxic agent. Methodology Results: cellulose-chitosan (BC-Chs) hydrogels were synthesized insitu, dried, immersed in (Gp) solution yield BC-Chs crosslinked hydrogel (BC-Chs-Gp) characterized. presence of amide 1 II was revealed FT-IR SEM showed BC-Chs-Gp had compact fibril Low tensile strength, less swelling ratio moisture exhibited crosslinking. Hydrogels active against E. coli S. aureus. In vitro drug release studies using quetiapine fumarate followed Higuchi model super case transport mechanism non-Fickian for BC-Chs-Gp. Conclusion Application findings. utilized non-pathogenic bacteria, G. Xylinus natural resource (coconut) obtain biocompatible hydrogels. BCChs prepared simple direct introduction Chs growing network BC subsequently ex-situ modification method. properties term ratio, content, antibacterial activity, their controlled ability make them suitable potential biomedicine, especially transdermal patches as wound dressing healing agents. Keywords: cellulose; Chitosan; Genipin; Biocompatibility; mechanical properties.